Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


Detector for Toxic Substances Developed
December 29, 2009 13:35


Cooperation of several research institutes of Russian Academy of Sciences resulted in creation of a new high-precision sensor for detecting substances, hazardous and toxic for DNA.

Accurate and fast detection of potential toxins is extremely important for human health and environment. A close eye should be kept on chemical substances, which are able to interact with DNA, because killing effects of mutagens and carcinogens can be detected years after the exposure to these substances. Combination of nanotechnologies with biotechnologies can result in a new solution to the problem.

An elegant idea of the Russian researchers is using nano-sized constructions of DNA molecules, which change their optical properties, when interacting with toxic compounds. In their turn, changes in optical properties can be detected with a unique sensor, which was developed by the Russian scientists. Authors of the technique claim that new generations of their sensors will be smaller in size and cheaper than the prototype, because they target structural elements of nano-sized constructions, which are nanosensors themselves.

The prototype of a new bio-sensor system has successfully passed first tests and can find application in various medical institutions, where direct detections of substances, toxic for DNA, are performed in liquids. DNA molecules, immobilized in optically transparent, isotropic and chemically neutral gels and showing anomalous optical activity, are used as integral biosensors. As a registering devices scientists suggest using a portable single-wave dichrometer, which converts optical signal of circular dichroism.

Biohazard
Biohazard sign
Micro-sized DNA constructions (about 0.5 micrometer in diameter) are made from double-stranded DNA molecules by means of nano-bridges (chelate links, consisting of alternating molecules of daunomycin, an antracyclic antibiotic, and copper ions Cu2+) between neighboring molecules, immobilized in a spatial structure of lyotropic cholesteric liquid-crystal dispersion. Particles of this dispersion are immobilized in advance on a synthetic polymer matrix, which is a result of three-dimensional radical polymerization of bis-micromonoper of polyethylene oxide. Parameters of three-dimension structure of polyethylene oxide provide strong fixation of DNA molecular constructions without breaking their spatial organization and reactive capability for long period of time under room temperature conditions.

Formation of DNA nano-structures is accompanied by anomalous optical activity in the absorption region of daunomycin chromophores, which is about 520 nanometers. Presence and concentration of biologically active substances in sample liquid, which diffuses into hydro-gel, can be detected via values of biosensor signal change, registered by a dichrometer in a abovementioned wavelength of visible light range. New detector can also be used for measuring diffusion rates for various liquids in gel nano-biomaterials.

Source: Science & Technologies

Kizilova Anna


Tags:      

Next Previous

You might also find interesting:

Saga about Neutrons Manganese Tells About Your Blood Vessels Health Best Milk Bacteria for Tasty Foods Nanoparticles Fight Cancer Cells 83 Russian Inventions that Made the World as It Is





comments powered by Disqus




Comment on our site


RSS   twitter   facebook   submit

Bookmark and Share


TAGS:
Russian festivals  Denis Davydov  Mercedes-Benz Fashion Week Russia  Russian churches  Astrakhan Region  Russian artists  Festivals in Moscow  Security System  St. Petersburg  Theatre  litvinov  train tickets Russia FIFA  Oleg Krotkov  Cancer  Russian Cinema  Russian business  Archeological Finds  Andrey Sigle  Novosibirsk  defense  Russian regions  Ryazan oblast  IT  Cultural Olympiad   Konigsberg Castle  Latvian visa centre  Sberbank  Biysk  Russian actors  Isaak Dunayevsky  Russian economy  Chelyabinsk Zinc Plant  Russian visa  Russian government  The Voice of Nomads  Russian opera  Kamensk-Uralski  Academicians  Russian Miniature Painting  travel to Russia  Winter Sports  Exhibitions in Moscow  Moscow  Tel Aviv  Russian tourism  Folk Arts  Vologda  aircraft  Russian mobile operators  Resources 


Travel Blogs
Top Traveling Sites