Biologically active peptides or peptide bio-regulators are known to reduce development frequency of some tumors and to increase average life expectancy. Russian scientists from carcinogenesis and onco-gerontology of the Research Institute of Oncology have studied effects of peptide bio-regulating molecules for 35 years and finally decided to share their results with the public.

Most experiments were performed on laboratory animals – mice and rats, however, some pharmaceuticals have already been introduced in clinical practice. Researchers based their studies on the fact that tumor growth is a multistage process, and it can be stopped on early stages by means of some kind of therapy. Cancer is often connected with ageing, and the longer organism lives, the weaker thymus and pineal gland, which are main organs of immune and neuroendocrinal systems, work. Researchers suggest fighting cancer growth in laboratory animals by means of injections of regulatory peptides with low molecular weight. These essential peptides are usually synthesized in healthy organisms by abovementioned glands and are, what ageing organisms lack.

 

 

Scientists have extracted peptides called “thymalin” from thymus and “epithalamin” from pineal gland, moreover, they used chemically synthesized analogues of these substances, which consisted of 2-4 amino acids. These analogues were called thymogen, vilon, epythalon and delta sleep-inducing peptide (DSIP). Bioregulators were injected to animals for quite a long period of time, starting with 2-month-old babies until their natural death. Experiments have shown that short peptides increase average life expectancy and reduce development frequency of spontaneous and sometimes even induced tumors. These organic substances are tissue-specific, do not cause allergic reactions and aren’t toxic. Researchers believe that peptides regulate functioning of some certain genes.

At the present moment two peptide bio-regulators, thymalin and epithalamin, have successful passed long-term complex tests in the Institute of Bioregulation and Gerontology (North-Western branch of Russian Academy of Medical Sciences) and Institute of Gerontology (Ukrainian Academy of Medical Sciences). Annual course ingestion of these substances improved functioning of brain, immune, endocrine and cardio-vascular systems, as well as increased density of bone tissue. All mentioned factors led to statistically reliable decrease in mortality of those patients, who took peptide medication. Thymalin also caused two-fold decrease of cases of acute respiratory diseases. Epithalamin was a treating agent for 349 patients with various forms of cancer: breast cancer, cervical and endometrial cancer, ovarian cancer, as well as lung, stomach and esophageal squamous cell cancer. The agent relieved intoxication symptoms, improved overall health of all patients, slowed down tumor progress and reduced risk of recurrence.

Scientists believe that results obtained open prospects for using new bio-regulating peptides for prevention of malignant growth in human beings.

Source: Science & Technologies

Kizilova Anna