Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


Healing Bones Now Faster
March 2, 2011 18:02


A fibrin clot

Russian researchers have suggested a new technique for accelerating healing of damaged and broken bones. The “magic” substance, used for this purpose, is called fibrin.

Fibrin is a protein, synthesized by an organism, when its system of blood coagulation gets activated. Fibrin fibers form a clot skeleton, thus protecting injured place from blood loss and from infection spread. Fibrin clots are widely used in medical practice – for bleeding control after tooth extraction in dentistry, for instance. However, information whether these clots are able to enhance bone tissue regeneration, is rather scarce. That is why biochemists and medics from Novosibirsk tried to find out whether fibrin really worked for faster bone regeneration.

The experiment was held on laboratory rats with artificially damaged bones of lower jaw. Medics consider best therapeutic effect to form, when fibrin clots used for therapy are made from a patient’s blood. However, in the experiments with rats, fibrin clots belonged to rats other, than those, which participated in the research; however, all rats belonged to one line and were genetically very close.

Researchers worked with rats’ lower jawbone, which is a wide and strong bone, easy to work with. Another reason for choosing this bone is that rats aren’t able to get rid of stitches. Scientists made a round hole in these bones – using anesthesia, of course. Half of animals received a fibrin clot in their injury – this was a test group. Each week during a 5-week period, bones of rats were analyzed by means of light microscopy and X-ray examination.

 

 

After one week, holes in a lower jawbone of rats without the fibrin clot were filled with blood, and the injury’s margins contained fragments of a loose connective tissue. After two weeks, control group showed full coverage of the injury with cartilaginous tissue. In three weeks a new bone formed with only some signs of an injury. Fourth and fifth weeks brought almost full recovery from the injury.

As for rats, which bone injury was covered with a fibrin clot, early recovery stages appeared to be shorter – fragments of a new bone appeared as soon as in one week. Examinations of the test group of laboratory rats in two, three, four and five weeks after treatment showed similar recovery pattern as shown for rats from the control group. Researchers demonstrated that bones with fibrin clots recovered faster, than bones without any treatment – full recovery was detected in two weeks with fibrin, and in three weeks without fibrin.

A fibrin clot soothes an inflammation process, which starts in an injury. Moreover, this clot serves as a skeleton, which helps immune cells, as well as connective tissue cells, to move along the clot. Researchers, who showed that new bone formed faster with fibrin treatment, explain this phenomenon with formation of a new bone starting right after fibrin introduction – without losing time for lysis and removal of a blood clot with large amount of erythrocytes.

 

 

Source: Science & Technologies

Kizilova Anna


Tags: Russian Scientists Russian medicine    

Next Previous

You might also find interesting:

Experts From Ulyanovsk Technology Transfer Center Developed Two Unique Tests Crab Shells Protect Your Favourite Cheeses Human Beings and Apes Unite their Creativity Scorpion Toxins to Fight Harmful Insects Sunscreen Made of Silicon Nanoparticles









Comment on our site


RSS   twitter      submit



TAGS:
Lipetsk Region  Moscow  Canada  Exhibitions in St. Petersburg  The State Russian Museum  Russian army  Ust-Buotama  Murmansk Region  The Romanov Family  Russian business  Primorsky Territory  Russian football team  Kirill Lavrov  Russia archaeology  Mikhail Lermontov  Ballet Dancers  Russian Cinema  Dmitri Shorin  Smoking in Russia  human rights in Russia  Energy Saving  economic crisis  Historians  Climate  Khodorkovsky  Russian tourism  Russian science  Presidential Research Projects Program  Astrakhan Region  Kari  Mikhail Yelizarov  IPO in Russia  Russian Lakes  Chelyabinsk  textile  Russian scientists  Russian Rock  Russian naval forces  Russian circus  Russian Nature  Film Distribution  Erwin Wurm  Russian economy  Film Festivals  Mercedes-Benz Fashion Week Russia  Russian media  Emile Galle  Exhibitions in Moscow  international cooperation  St. Petersburg 


Travel Blogs
Top Traveling Sites