Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


Psoriasis and Atherosclerosis Anything in Common?
July 6, 2011 20:11


What are genes?

Research, performed in Russia and other countries, revealed that formation processes of psoriatic and atherosclerotic plaques could have common mechanisms.

Russian scientists decided to find out what role genes of ATF family play in development of these two diseases – psoriasis and atherosclerosis. Working group of this project consisted of researchers from Vavilov Institute of General Genetics (Russian academy of sciences), the Centre of Biological Therapy, the Centre of Theoretical Problems of Physico-Chemical Pharmacology, and Sechenov First Moscow State Medical University. The research was financially supported by the Russian government and Russian academy of sciences. Experiments demonstrated that abovementioned genes changed their activity both in atherosclerotic plaques of blood vessel walls, and in psoriatic plaques on skin.

In order to perform experimental work, researchers compared atherosclerotic plaques with healthy parts of a blood vessel, as well as searched for difference between psoriatic plaques and tiny bits of healthy skin in psoriasis patients. Scientists have measured activity of two genes of AT F family. These two genes are ATF-3 and ATF-4, and their activity in damaged blood vessel tissue turned out to be two times higher, than in healthy tissue. In case of psoriasis the pattern was completely opposite – activity of mentioned genes in psoriatic plaques appeared to be two times lower compared to same process, taking place in healthy skin tissues.

Patients, which were so kind to give biological material for analysis, had other health disorders apart from psoriasis or atherosclerosis. These concomitant diseases were various types of cancer, gastric ulcer, duodenal ulcer, and others. However, investigation showed that mentioned pathological processes had no effect on activity of ATF-3 and ATF-4 genes, unlike psoriasis and atherosclerosis. Experiments also clarified that stage and severity of psoriasis or atherosclerosis didn’t have any effect on intensity of expression of these genes.

Scientists explained changes in activity of these genes with ATF-3 playing an important role in death of cells, lining blood vessels, during development of atherosclerosis. As for ATF-4, this gene regulates and activates ATF-3. Authors of the research consider difference of gene activity in psoriatic and atherosclerotic plaques to be a good parameter for diagnostics of these two diseases.

Psoriasis is a very common skin condition, during which people have irritant red skin. It may happen at any age, but is most often detected in people aged between 15 and 35. The disease seems to have links with heredity.

During atherosclerosis fat is accumulated inside blood vessels in the form of atherosclerotic plaques. These plaques may eventually block the vessel and cause unpleasant symptoms, like chest pain, short breath, heart attack and others. One with atherosclerosis usually doesn’t feel any discomfort, until blood flow is blocked. Blood clots can form near the plaques.

Source: Science & Technologies

Anna Kizilova


Author: Anna Kizilova

Tags: health biology medicine Russian academy of sciences genetics 

Next Previous

You might also find interesting:

Mercury's Core Is Liquid Top 10 Russian Innovations Noise That Helps Us 127 Meters of Evolution Scientists Fight Hyperammonemia









Comment on our site


RSS   twitter   facebook   submit

Bookmark and Share

search on the map
TAGS:
Collecting  gold reserves  Innovations  Festivals in Moscow  Russia's foreign debt  Moscow World Fine Art Fair   Russian tourism  Exhibitions in Moscow  Russian Cinema  St. Petersburg  Anatoly Kokorin  Tretyakov Gallery  Russian Museum  Detinets  bike rental  Alexei Batalov  Leo Tolstoy  Russian cities  The Beatles Club  Mercedes-Benz Fashion Week Russia  Republic of Bashkortostan  The Golden Ring of Kuzbass  Archeological Finds  Visa   Russian business  Tula Region  Exhibitions in Saint Petersburg  La Roux  Moscow  Archaeology  Moscow Zoo  Burial Grounds  Gidon Kremer  Samara  Elvira Nabiulina  History Museums  Valery Gergiev  Persian Leopards   Roshen  Egan-Jones Ratings  Primorye Region  Film Distribution  Nonna Mordyukova  Russian regions  Perm Territory  Russian winter  Russian models  Grigory Bobrovsky  travel to Russia  Russian football team 


Travel Blogs
Top Traveling Sites