Add to favorite
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS

Microcapsules to Carry DNA-Vaccines
February 24, 2009 18:44


Russian scientists developed a general technique for producing micro-containers, which will be perfect for creating DNA-vaccines, able to provide stable and powerful immunity for those, who take them. These containers have multilayer biodegradable shell, which can host proteins, DNA and other molecules.

The world knows little about such micro-containers for DNA delivery. Shells of foreign containers consist of polylactic acid, and such capsules are the basis for vaccines against hepatitis and HIV. Russian biochemists suggest the simplest ever technique for producing such containers – no complex equipment, only bench centrifuge is required.

Researchers place protein, DNA or any other substance they want to be delivered inside an organism, inside a porous microsphere, made of calcium carbonate (CaCO3). Then they cover the microsphere with a semipermeable membrane, containing several layers of natural polymers – polysaccharides. The sphere can also be covered with polypeptides or composite shell. When microspheres, covered with polymers, get into an acidified solution, calcium carbonate dissolves and leaves the sphere through the polymer membrane, leaving protein or DNA ready for transportation.

Tiny capsules for DNA-vaccines have about 1-2 microns in diameter, and they can become even tinier, if we take smaller carbonate spheres. Such capsules can be injected subcutaneously or even directly in blood. Small size provides free flowing of these capsules along blood vessels, since they are smaller than erythrocytes and change shape when traveling through narrow capillaries. Cells “absorb”capsules, and their shell dissolves, releasing active “filling”.



The technique allows delivery of treating agents to cells that need therapy, as well as prolongation and regulation of action time. When we insert an enzyme, splitting container membrane, into microcapsule together with DNA or other treating molecule, we can regulate the process of treating agent release – the lesser amount of enzyme we put inside the capsule, the slower its membrane deteriorates. Russian biochemists have successfully tested their capsules on mice and cell lines. Common vaccine contains proteins of viruses or bacteria, and DNA-vaccine – genes, which encode said proteins. Antigen proteins of a common vaccine usually decompose rapidly, since they are alien for organisms, which are subject to vaccination. The same happens with non-capsulated DNA – appropriate enzymes break it. DNA in microcapsules helps an organism produce its own antigen, forming immunity. This process is slow, since capsules dissolve for at least one month and maintain antigen concentration, necessary for stable immunity.

Scientists claim that injections are not the only way to deliver DNA-vaccines to an organism. Microcapsules can get inside you by means of sprays, which can be dispersed on oral or nasal mucous coat and for immunity against some certain disease. Researchers consider DNA-vaccines to be the future of medicine, and it becomes closer with new technique for their delivery into an organism. However, delivering therapy to ailing organ is not the only application of developed technique.

Source: Science & Technology

Kizilova Anna

Tags: Russian technologies Russian medicine    

Next Previous

You might also find interesting:

Ebola Virus Vaccine Passed First Stage of Clinical Trials in Novosibirsk Russian and American Scientists Created Capsule-Trap for Dangerous Diseases Right Cerebral Hemisphere Catches Meaning and Left One Chooses Words Making Gold Ingots from Gold Dust Russia Can Build a New Fast Neutron Reactor within 10 Years

Comment on our site

RSS   twitter      submit

Avant-Garde Art  Pussy Riot case  Puppet Theatre  Russian economy  Nadezhda Savchenko  Russian Spacemen  book hotels in Russia  BEssARION  Modern Russian Literature  Russian politicians  Russian tourism  Alexander Kitayev  Tambov Region  six-seat taxi   Political Caricature  Russian women  Russian painters  Syria  Ryazan Region  visa-free regime  Russian science  Moscow  Rokot  migration in Russia  Infill Building  Khabarovsk  Russian scientists  Eldorado  Russian Cinema  Russian business  Yuri Gagarin  Russian Avant-Garde  Russian social networks  Russian models  Pobeda  Exhibitions in Moscow  Military Technical Museum  banned books  Boris Nemtsov  Sceince  Mercedes-Benz Fashion Week Russia  Lipetsk   Vika Gazinskaya  Russian Music Instruments  Mikael Tariverdiev  Alisher Usmanov  Blondie  St. Petersburg  Republic of Tatarstan  Moscow hotels 

Travel Blogs
Top Traveling Sites