Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


Early Diagnostics of Schizophrenia is Now Possible
March 17, 2009 16:47


The most severe form of schizophrenia – chronic schizophrenia – is hereditary. Descendants in the male line can have genetic disposition to this disease. Russian scientists from the Centre of Mental Health of Russian Academy of Medical Sciences found out the genotype, which was common for men, suffering from a chronic form of schizophrenia. Results of this study can become the basis for development of a test system for early diagnostics of schizophrenia, which is especially important in case of such a terrible disease.

Latest studies showed that a certain protein called “brain-derived neurotrophic factor” (BDNF) can be related to pathophysiologic mechanisms of schizophrenia. Brain-derived neurotrophic factor regulates growth, differentiation and development processes of neurons. Moreover, BDNF is involved into processes, linked with brain’s synaptic flexibility. Researchers showed that replacing only one amino acid valine, located at certain position on protein’s molecule, with methionine was enough to disturb cellular distribution of the protein. The result is low concentration of mature protein in respective parts of brain, and as a consequence neurons of frontal cortex stop functioning properly, which leads to schizophrenia development.

 

 

 
How does “wrong” protein form? A gene, responsible for BDNF synthesis, is located on the 11th chromosome and exists in two forms or alleles – valine variant and methionine variant. Every human being has two copies of the mentioned gene, since we get one chromosome from our mother, and another – from our father. Knowing this, scientists supposed that three variants of gene combination could exist: first is when people have valine in both copies of BDNF-coding gene (Val/Val); second is having two methionines (Met/Met) in this gene; and the third is when people receive one valine and one methionine (Val/Met) copy of the gene.

Fellows of the laboratory of clinical genetics (the Centre of Mental Health of Russian Academy of Medical Sciences) were the first to perform a massive study of allele frequencies for BDNF-coding gene on Moscow dwellers. The study involved 783 patients with schizophrenia and 633 healthy volunteers. Chronic form of schizophrenia is much more severe than episodic form, during which symptoms disappear from time to time. Experiments revealed that chronic schizophrenia in men was linked with Val/Val allelic variant – male patients with this disease had Val/Val gene type 1.3 times oftener than healthy men did. As for women, all allelic variants occurred with the same frequency despite the fact of being ill or healthy.

Of course, scientists know that schizophrenia is a polymorphous disease, and its development depends on many genes. However, their study allows building a test-system for detection of high-risk group. Early diagnostics provides starting immediate therapy, which is a very important factor for such disease as schizophrenia.

Source: Living Systems

Kizilova Anna


Tags: Russian medicine     

Next Previous

You might also find interesting:

Why We Read Everything We See No Acid in Your Eyes What You Should Know About Sweeteners Advances in Nanotechnologies: Reusable Nano-Containers Hydrogen from Bacteria New Source of Fuel









Comment on our site


RSS   twitter      submit



TAGS:
Moscow airports  Vitas  Russian Cinema  Nikolay Punin  Novospasskoye  Astrakhan  Russian security service  Russian business  Vologda  Vladivostok  Russian sport transfers  Russian science  Moscow  Darwin Museum  travel mobile applications  Russian Nature  Bor  Russian aviation  St. Petersburg  Mercedes-Benz Fashion Week Russia  the Crimea  Dankov  Mortality Rate  Khabarovsk  investment  Alisher Usmanov  Exhibitions in St. Petersburg  Moscow State History Museum  City Hunter  Cancer  Russian economy  Russian sculptures  Exhibitions in Moscow  Parliament in Action  Book Tickets for Ballet  Sochi 2014  air carriage fare  Vitaly Mutko  Russian actors  Nicholai Roerich  Peterhof  Russian tourism  Moscow Helsinki Group Award  Russian scientists  Russian travelers  Khanty-Mansi Autonomous Okrug  Jean-Maurice Ripert  Russian labor market  North Caucasus  Russian film industry 


Travel Blogs
Top Traveling Sites