Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


Early Diagnostics of Schizophrenia Is Now Possible
March 17, 2009 16:47


The most severe form of schizophrenia chronic schizophrenia is hereditary. Descendants in the male line can have genetic disposition to this disease. Russian scientists from the Centre of Mental Health of Russian Academy of Medical Sciences found out the genotype, which was common for men, suffering from a chronic form of schizophrenia. Results of this study can become the basis for development of a test system for early diagnostics of schizophrenia, which is especially important in case of such a terrible disease.

Latest studies showed that a certain protein called brain-derived neurotrophic factor (BDNF) can be related to pathophysiologic mechanisms of schizophrenia. Brain-derived neurotrophic factor regulates growth, differentiation and development processes of neurons. Moreover, BDNF is involved into processes, linked with brains synaptic flexibility. Researchers showed that replacing only one amino acid valine, located at certain position on proteins molecule, with methionine was enough to disturb cellular distribution of the protein. The result is low concentration of mature protein in respective parts of brain, and as a consequence neurons of frontal cortex stop functioning properly, which leads to schizophrenia development.

Brain-derived
Brain-derived neurotrophic factor
How does wrong protein form? A gene, responsible for BDNF synthesis, is located on the 11th chromosome and exists in two forms or alleles valine variant and methionine variant. Every human being has two copies of the mentioned gene, since we get one chromosome from our mother, and another from our father. Knowing this, scientists supposed that three variants of gene combination could exist: first is when people have valine in both copies of BDNF-coding gene (Val/Val); second is having two methionines (Met/Met) in this gene; and the third is when people receive one valine and one methionine (Val/Met) copy of the gene.

Fellows of the laboratory of clinical genetics (the Centre of Mental Health of Russian Academy of Medical Sciences) were the first to perform a massive study of allele frequencies for BDNF-coding gene on Moscow dwellers. The study involved 783 patients with schizophrenia and 633 healthy volunteers. Chronic form of schizophrenia is much more severe than episodic form, during which symptoms disappear from time to time. Experiments revealed that chronic schizophrenia in men was linked with Val/Val allelic variant male patients with this disease had Val/Val gene type 1.3 times oftener than healthy men did. As for women, all allelic variants occurred with the same frequency despite the fact of being ill or healthy.

Of course, scientists know that schizophrenia is a polymorphous disease, and its development depends on many genes. However, their study allows building a test-system for detection of high-risk group. Early diagnostics provides starting immediate therapy, which is a very important factor for such disease as schizophrenia.

Source: Living Systems

Kizilova Anna


Tags:      

Next Previous

You might also find interesting:

Cell Carrier Made Of Titanium Long Live OLEDs Improved Scanning Microscopes for Nanotechnologies Very Light Aircraft Almost Like a Feather Table Therapy Makes Healthier









Comment on our site


RSS   twitter   facebook   submit

Bookmark and Share

-8

search on the map
TAGS:
Russian tourist destinations  Stanislav Cherchesov  Russian politicians  Japanese Film Festival  Russian festivals  Sakhalin  Theatre  Russian Cinema  Russian Literature  Russian business  Giles Deacon  Yekaterinburg  Daniil Kharms  St. Petersburg  Russian tourism  Russia archaeology  Romanovs  Russian hotels  pavel  Contemporary Writers  Russian history  corruption in Russia  Moscow  alcohol market  Archeology  Gennady Troshkov  Tourism and hospitality Forum   Domodedovo  Regional Cuisines  Guinness Book of Records  Rostov  Russain gas companies   Mercedes-Benz Fashion Week Russia  Karasuk  Wimbledon  IT  Russian sportsmen  Amursk  Bolshoi Theatre  Maria Sharapova  Renault  Crimea  Nikolay Radlov  The House-Museum of Pushkin's Uncle  health  Krasnoyarsk tours  Exhibitions in Moscow  Konstantin Khabensky  Fashion Illustration  Historical Exhibitions 


Travel Blogs
Top Traveling Sites