Add to favorite
 
123
Subscribe to our Newsletters Subscribe to our Newsletters Get Daily Updates RSS


New Anti-Epileptic Agent Discovered
March 31, 2009 17:01


Scientists from the Russian city of Novosibirsk currently work on developing new effective and cheap anticonvulsants, which are also less toxic than existing anti-epileptic drugs.

Patients with epilepsy desperately need effective and non-toxic treating agents. Researchers from Novosibirsk Institute of Organic Chemistry (Siberian branch of Russian Academy of Sciences) suggest making anticonvulsants, based on pinene amino acids. Scientists have already performed some pharmacology studies of the new drug on non-pedigree laboratory mice.

Statistics says that about 3 per cent of Earth’s population suffers from epileptic seizures to a greater or lesser degree. In order to prevent convulsions, doctors usually recommend their patients to take pharmaceuticals, containing gamma-aminobutyric acid. However, this kind of therapy is almost useless for about one fourth of epileptics. That is why doctors and scientists continue their search for anticonvulsants, which are more effective than existing ones and have as little side effects as possible.

Basic substances for such therapeutic agents can vary, and amino acid derivatives, for instance, which are produced from alpha-pinenes, fit perfectly, researchers from Novosibirsk think. Alpha-pinenes belong to hydrocarbons of terpene type and are among most common natural terpenes – pine needle oil (turpentine) contains many of these chemical compounds, for example. Amino acids from alpha-pinenes have rigid structure and are more selective during binding with target molecules. During studies scientists also discovered that abovementioned chemical compounds showed higher biological activity than derivatives of gamma-aminobutyric acid.

 

 

 
Anticonvulsant activity of new possible therapeutic agents was tested on white non-pedigree mice, which received intraperitoneal injections of pentylenetetrazol and nicotine, which are well-known drugs, affecting nervous system and causing convulsions. Amino ester of an amino acid, belonging to alpha-pinenes, showed great anticonvulsant activity in 7-fold dilution compared to Phenobarbital, a common anticonvulsant agent. Moreover, this substance showed only a slight effect on general emotional state and motion behaviour. In addition, said amino ester causes no sleepiness and has moderate toxicity level.

Median lethal dose (LD50) of new possible anticonvulsant is 8.1 times less than that of Phenobarbital and exceeds 1000 mg (1 g) of the drug per one kilogram of body weight, when introduced intragastrically – scientists claim you should eat a lot of this drug before it does you any harm.

All abovementioned properties of the amino ester and simple extraction technique (it contains only two stages) from a common substance – alpha-pinene – allow scientists to suggest this derivative becoming the basic substance for development of new almost non-toxic anticonvulsant agents, thus making life of epilepsy patients easier.

Source: Science & Technology

Kizilova Anna


Tags: Russian medicine     

Next Previous

You might also find interesting:

Healing Bones Now Faster Scientists Fight Hyperammonemia Bee Hives as Thermostats New Treating Agents from Kelp Scientists Designed New Way of Infrared Absorption









Comment on our site


RSS   twitter      submit



TAGS:
Aleksey Mordashov  Andrey Zvyagintsev  Russia  Russian business  South Stream  Orthodoxy  Russian National Village  Musicals in Moscow  Mercedes-Benz Fashion Week Russia  Exhibitions in Moscow  The Ministry of Transport  Alyosha Dmitrievich  Russian language  Tatyana Navka  South Park  Kalashnikov machine gun  heat  St. Petersburg  Urals  Taganrog  Murmansk Region  Russian science  Olympics 2012  Formula 1 Sochi  tour operators  Leonid Yarmolnik  Tretyakov Gallery  Lev Borodulin  Russian education  Maria Callas  Russian scientists  Mikhail Prokhorov  Exhibition in Moscow  Russian biologists  Russian airports  Russian economy  Events in Moscow  Galina Vishnevskaya Opera Singing Center  Russian tourism  Russian children  Arkhangelsk  Moscow  satellite  Russian Cinema  Igor Starygin  Institute of Russian Realist Art   Russian oil companies  criminality  expats in Russia  Russian roads 


Travel Blogs
Top Traveling Sites